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REACH

DYNAMICS OF THE IMMUNE RESPONSE AND CLIMATE CHANGE ADAPTATION

The REACH team aims at deciphering the molecular bases of the interaction between pathogens and their host plants in the context of climate change. Pathogen perception mediated by intracellular immune receptor of the NLR (nucleotide-binding Leucine rich repeat receptor) family constitutes a crucial step determining the issue of the interaction. Upon pathogen effector recognition, NLRs initiate effector-triggered immunity (ETI) that involves a rebooting of PTI-associated transcriptional reprogramming and often localized host cell death at sites of attempted pathogen infection.

Despite intensive efforts in the field, a major gap remains in our understanding of (i) how NLRs are activated by specific pathogen effectors and (ii) how the active state of these receptors connect to downstream signaling events occurring during ETI. To address those fundamental questions, we use use  complementary cellular biology, molecular genetic, genomic and biochemical approaches toinvestigate the molecular events involved in ETI conditioned by plant immune receptors.

 In a context of global climate change, expanding our knowledge of the interplay between plant immunity and temperature elevation is critical for developing sustainable disease resistance strategies. This includes investigating the crosstalk between NLR-mediated immunity and temperature stress responses and the identification and characterization of yet uncovered genetic sources confering robust resistance

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RESEARCH THEMES

Main research axes currently developed in the REACH group :

 

- Virulence activities of bacterial effectors (L. Deslandes, V. Pacquit)

 

- Nuclear activities of a plant immune receptor complex (D. Tremousaygue, L. Deslandes, P. Dabos)

 

- NLR-mediated immunity at the root-level (M. Marchetti)

 

- Sensing and signalling activities of plant NLRs under heat stress (M. Bernoux, C. Vicédo)

 

- Genetic bases of robust resistances and alternatives to face pathogens in fluctuating climates (R. Berthomé)

 

MEMBERS

Heloise Demont

PhD student

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Matilda Zaffuto

CDD

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PUBLICATIONS

DYNAMIC LIST